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Melissa's husband was in Washington, D.C. on the day of the Change, and probably died soon after. Melissa lived in Sutterdown with her mother and daughter, Tamar.
In Dies the Fire, when Juniper Makenzie and the Reverend Dixon's Sutterdown Evangelists attacked a group of soldiers from the Portland Protective Association, Melissa was there with Tamar. When Tamar asked Juniper if she could do magic, Juniper produced a Snickers bar by sleight-of-hand.
After the battle, she returned to Sutterdown.
Later, she married Sam Aylward and had a number of children, including Edain Aylward Mackenzie, Fand, and Dick. She became a High Priestess of the Mackenzies. Her mother had problems remembering that the Change had happened, and often complained about the lack of chocolate, coffee and rice.
At the nemed, Melissa had a vision of the death of Pope Benedict XVI with Luke Hutton in attendance.